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Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing

Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding evolutionary and molecular processes. In this report, we analyze spontaneous mutations accumulated over thousands of generations by wild-type Escherichia coli and a derivative defective in mismatch repair (MMR),...

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Bibliografiske detaljer
Main Authors: Lee, Heewook, Popodi, Ellen, Tang, Haixu, Foster, Patricia L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478608/
https://ncbi.nlm.nih.gov/pubmed/22991466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210309109
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