Determinants of Base-Pair Substitution Patterns Revealed by Whole-Genome Sequencing of DNA Mismatch Repair Defective Escherichia coli

Mismatch repair (MMR) is a major contributor to replication fidelity, but its impact varies with sequence context and the nature of the mismatch. Mutation accumulation experiments followed by whole-genome sequencing of MMR-defective Escherichia coli strains yielded ≈30,000 base-pair substitutions (B...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Foster, Patricia L., Niccum, Brittany A., Popodi, Ellen, Townes, Jesse P., Lee, Heewook, MohammedIsmail, Wazim, Tang, Haixu
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2018
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063221/
https://ncbi.nlm.nih.gov/pubmed/29907647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301237
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