High Glucose Inhibits the Aspirin-Induced Activation of the Nitric Oxide/cGMP/cGMP-Dependent Protein Kinase Pathway and Does Not Affect the Aspirin-Induced Inhibition of Thromboxane Synthesis in Human Platelets

Since hyperglycemia is involved in the “aspirin resistance” occurring in diabetes, we aimed at evaluating whether high glucose interferes with the aspirin-induced inhibition of thromboxane synthesis and/or activation of the nitric oxide (NO)/cGMP/cGMP-dependent protein kinase (PKG) pathway in platel...

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Autores principales: Russo, Isabella, Viretto, Michela, Barale, Cristina, Mattiello, Luigi, Doronzo, Gabriella, Pagliarino, Andrea, Cavalot, Franco, Trovati, Mariella, Anfossi, Giovanni
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2012
Materias:
Pathophysiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478557/
https://ncbi.nlm.nih.gov/pubmed/22837307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0040
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