Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral adipose tissue–derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from E...

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Detalhes bibliográficos
Main Authors: Nakatsuka, Atsuko, Wada, Jun, Iseda, Izumi, Teshigawara, Sanae, Higashio, Kanji, Murakami, Kazutoshi, Kanzaki, Motoko, Inoue, Kentaro, Terami, Takahiro, Katayama, Akihiro, Hida, Kazuyuki, Eguchi, Jun, Horiguchi, Chikage Sato, Ogawa, Daisuke, Matsuki, Yasushi, Hiramatsu, Ryuji, Yagita, Hideo, Kakuta, Shigeru, Iwakura, Yoichiro, Makino, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478540/
https://ncbi.nlm.nih.gov/pubmed/22837305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0232
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