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Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment
Lysosomal storage diseases are characterized by deficiencies in lysosomal enzymes, allowing accumulation of target substrate in cells and eventually causing cell death. Enzyme replacement therapy is the principal treatment for most of these diseases. However, these therapies are often complicated by...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3478093/ https://ncbi.nlm.nih.gov/pubmed/18688246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1484 |
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