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Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain

The mode of action of clozapine, an atypical antipsychotic approved for treating schizophrenia and bipolar disorder (BD) mania, remains unclear. We tested for overlap with the actions of the mood stabilizers, lithium, carbamazepine and valproate, which downregulate arachidonic acid (AA) cascade mark...

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Bibliographic Details
Main Authors: Kim, Hyung-Wook, Cheon, Yewon, Modi, Hiren R., Rapoport, Stanley I., Rao, Jagadeesh S.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478065/
https://ncbi.nlm.nih.gov/pubmed/22414961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-012-2671-7
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