Persistence of Repair Proteins at Unrepaired DNA Damage Distinguishes Diseases with ERCC2 (XPD) Mutations: Cancer-Prone Xeroderma Pigmentosum vs. Non-Cancer-Prone Trichothiodystrophy

Patients with xeroderma pigmentosum (XP) have a 1,000-fold increase in ultraviolet (UV)-induced skin cancers while trichothiodystrophy (TTD) patients, despite mutations in the same genes, ERCC2 (XPD) or ERCC3 (XPB), are cancer-free. Unlike XP cells, TTD cells have a nearly normal rate of removal of...

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Main Authors: Boyle, Jennifer, Ueda, Takahiro, Oh, Kyu-Seon, Imoto, Kyoko, Tamura, Deborah, Jagdeo, Jared, Khan, Sikandar G., Nadem, Carine, DiGiovanna, John J., Kraemer, Kenneth H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477783/
https://ncbi.nlm.nih.gov/pubmed/18470933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.20768
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