Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling

Functional analysis has shown that the missense gain-in-function KCNQ1 S140G mutation associated with familial atrial fibrillation produces an increase of the slow delayed rectifier potassium current (I(Ks)). Through computer modelling, this study investigated mechanisms by which the KCNQ1 S140G mut...

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Autores principales: Kharche, Sanjay, Adeniran, Ismail, Stott, Jonathan, Law, Phillip, Boyett, Mark R, Hancox, Jules C, Zhang, Henggui
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2012
Materias:
Computational Physiology and Modelling
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477754/
https://ncbi.nlm.nih.gov/pubmed/22508963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.229146
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