Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling

Functional analysis has shown that the missense gain-in-function KCNQ1 S140G mutation associated with familial atrial fibrillation produces an increase of the slow delayed rectifier potassium current (I(Ks)). Through computer modelling, this study investigated mechanisms by which the KCNQ1 S140G mut...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kharche, Sanjay, Adeniran, Ismail, Stott, Jonathan, Law, Phillip, Boyett, Mark R, Hancox, Jules C, Zhang, Henggui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2012
Schlagworte:
Computational Physiology and Modelling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477754/
https://ncbi.nlm.nih.gov/pubmed/22508963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.229146
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