Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling

Functional analysis has shown that the missense gain-in-function KCNQ1 S140G mutation associated with familial atrial fibrillation produces an increase of the slow delayed rectifier potassium current (I(Ks)). Through computer modelling, this study investigated mechanisms by which the KCNQ1 S140G mut...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kharche, Sanjay, Adeniran, Ismail, Stott, Jonathan, Law, Phillip, Boyett, Mark R, Hancox, Jules C, Zhang, Henggui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2012
Pynciau:
Computational Physiology and Modelling
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477754/
https://ncbi.nlm.nih.gov/pubmed/22508963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.229146
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