Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling

Functional analysis has shown that the missense gain-in-function KCNQ1 S140G mutation associated with familial atrial fibrillation produces an increase of the slow delayed rectifier potassium current (I(Ks)). Through computer modelling, this study investigated mechanisms by which the KCNQ1 S140G mut...

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Detalhes bibliográficos
Main Authors: Kharche, Sanjay, Adeniran, Ismail, Stott, Jonathan, Law, Phillip, Boyett, Mark R, Hancox, Jules C, Zhang, Henggui
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Computational Physiology and Modelling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477754/
https://ncbi.nlm.nih.gov/pubmed/22508963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.229146
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