Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes

In cardiac cells, Ca(2+) release flux (J(rel)) via ryanodine receptors (RyRs) from the sarcoplasmic reticulum (SR) has a complex effect on the action potential (AP). Coupling between J(rel) and the AP occurs via L-type Ca(2+) channels (I(Ca)) and the Na(+)/Ca(2+) exchanger (I(NCX)). We used a combin...

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Hlavní autoři: Livshitz, Leonid, Acsai, Karoly, Antoons, Gudrun, Sipido, Karin, Rudy, Yoram
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2012
Témata:
Computational Physiology and Modelling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477750/
https://ncbi.nlm.nih.gov/pubmed/22547631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.228791
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