Activation of Colonic Mucosal 5-HT(4) Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity

BACKGROUND & AIMS: 5-hydroxytryptamine receptor (5-HT(4)R) agonists promote gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions have restricted their availability. We tested the hypotheses that 5-HT(4) receptors are expressed in the colonic epithelium and...

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Hauptverfasser: HOFFMAN, JILL M., TYLER, KARL, MACEACHERN, SARAH J., BALEMBA, ONESMO B., JOHNSON, ANTHONY C., BROOKS, ELICE M., ZHAO, HONG, SWAIN, GREG M., MOSES, PETER L., GALLIGAN, JAMES J., SHARKEY, KEITH A., GREENWOOD–VAN MEERVELD, BEVERLEY, MAWE, GARY M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477545/
https://ncbi.nlm.nih.gov/pubmed/22226658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.12.041
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