Activation of Colonic Mucosal 5-HT(4) Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity

BACKGROUND & AIMS: 5-hydroxytryptamine receptor (5-HT(4)R) agonists promote gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions have restricted their availability. We tested the hypotheses that 5-HT(4) receptors are expressed in the colonic epithelium and...

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Detalhes bibliográficos
Main Authors: HOFFMAN, JILL M., TYLER, KARL, MACEACHERN, SARAH J., BALEMBA, ONESMO B., JOHNSON, ANTHONY C., BROOKS, ELICE M., ZHAO, HONG, SWAIN, GREG M., MOSES, PETER L., GALLIGAN, JAMES J., SHARKEY, KEITH A., GREENWOOD–VAN MEERVELD, BEVERLEY, MAWE, GARY M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477545/
https://ncbi.nlm.nih.gov/pubmed/22226658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.12.041
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