Prevention of Hepatocellular Adenoma and Correction of Metabolic Abnormalities in Murine Glycogen Storage Disease Type Ia by Gene Therapy

Glycogen storage disease type Ia (GSD-Ia), characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA), is caused by deficiencies in the endoplasmic reticulum (ER)-associated glucose-6-phosphatase-α (G6Pase-α or G6PC) that hydrolyzes glucose-6-phosphate (G6P) to gl...

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Hauptverfasser: Lee, Young Mok, Jun, Hyun Sik, Pan, Chi-Jiunn, Lin, Su Ru, Wilson, Lane H., Mansfield, Brian C., Chou, Janice Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477505/
https://ncbi.nlm.nih.gov/pubmed/22422504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25717
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