A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Formation of the death-inducing signaling complex (DISC) is a critical step in death receptor-mediated apoptosis, yet the mechanisms underlying assembly of this key multiprotein complex remain unclear. Using quantitative mass spectrometry, we have delineated the stoichiometry of the native TRAIL DIS...

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Detalhes bibliográficos
Main Authors: Dickens, Laura S., Boyd, Robert S., Jukes-Jones, Rebekah, Hughes, Michelle A., Robinson, Gemma L., Fairall, Louise, Schwabe, John W.R., Cain, Kelvin, MacFarlane, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477315/
https://ncbi.nlm.nih.gov/pubmed/22683266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.004
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