TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

Immunoglobulin (Ig) class switching is crucial for generating antibody diversity in humoral immunity and, if deregulated, also has severe pathological consequences. How the magnitude of Ig isotype switching is controlled is still poorly understood. Here we identify TANK-binding kinase 1 (TBK1) as a...

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Bibliographic Details
Main Authors: Jin, Jin, Xiao, Yichuan, Chang, Jae-Hoon, Yu, Jiayi, Hu, Hongbo, Starr, Robyn, Brittain, George C., Chang, Mikyoung, Cheng, Xuhong, Sun, Shao-Cong
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477307/
https://ncbi.nlm.nih.gov/pubmed/23023393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2423
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