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TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
Immunoglobulin (Ig) class switching is crucial for generating antibody diversity in humoral immunity and, if deregulated, also has severe pathological consequences. How the magnitude of Ig isotype switching is controlled is still poorly understood. Here we identify TANK-binding kinase 1 (TBK1) as a...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477307/ https://ncbi.nlm.nih.gov/pubmed/23023393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2423 |
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