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Dissociable Effects of the Cannabinoid Receptor Agonists Δ(9)-Tetrahydrocannabinol and CP55940 on Pain-Stimulated Versus Pain-Depressed Behavior in Rats

Cannabinoid receptor agonists produce reliable antinociception in most preclinical pain assays but have inconsistent analgesic efficacy in humans. This disparity suggests that conventional preclinical assays of nociception are not sufficient for the prediction of cannabinoid effects related to clini...

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Autors principals: Kwilasz, Andrew J., Negus, S. Stevens
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477211/
https://ncbi.nlm.nih.gov/pubmed/22892341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.197780
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