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An Abridged Transition State Model to Derive Structure, Dynamics and Energy Components of DNA Polymerase β Fidelity()
We show how a restricted reaction surface can be used to facilitate the calculation of biologically important contributions of active site geometries and dynamics to DNA polymerase fidelity. Our analysis, using human DNA polymerase beta (pol β), is performed within the framework of an electrostatic...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477174/ https://ncbi.nlm.nih.gov/pubmed/21739967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200790s |
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