Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells

Humanized mouse models offer a challenging possibility to study human cell function in vivo. In the huPBL-SCID-huSkin allograft model human skin is transplanted onto immunodeficient mice and allowed to heal. Thereafter allogeneic human peripheral blood mononuclear cells are infused intra peritoneall...

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Bibliografiske detaljer
Main Authors: de Oliveira, Vivian L., Keijsers, Romy R. M. C., van de Kerkhof, Peter C. M., Seyger, Marieke M. B., Fasse, Esther, Svensson, Lars, Latta, Markus, Norsgaard, Hanne, Labuda, Tord, Hupkens, Pieter, van Erp, Piet E. J., Joosten, Irma, Koenen, Hans J. P. M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477148/
https://ncbi.nlm.nih.gov/pubmed/23094018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045509
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