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Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice

Pancreatic islet endothelial cells have in recent years been shown to support beta-cell mass and function by paracrine interactions. Recently, we identified an islets endothelial-specific glycoprotein, thrombospondin-1 (TSP-1), that showed to be of importance for islet angiogenesis and beta-cell fun...

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Detalhes bibliográficos
Main Authors: Drott, Carl Johan, Olerud, Johan, Emanuelsson, Hanna, Christoffersson, Gustav, Carlsson, Per-Ola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477147/
https://ncbi.nlm.nih.gov/pubmed/23094049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047451
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