Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

BACKGROUND: Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing. Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy by deregulation of cell growth and division. Our previous pilot study with pair...

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Hlavní autoři: Xu, Jia, Shetty, Priya B, Feng, Weiwei, Chenault, Carol, Bast, Robert C, Hilsenbeck, Susan G, Yu, Yinhua
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476972/
https://ncbi.nlm.nih.gov/pubmed/22695491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-243
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