Metformin, an anti-diabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway

The biguanide metformin is widely used for the treatment of type II diabetes. Its anti-proliferative and pro-apoptotic effects in various tumor cells suggest its potential candidacy for cancer chemoprevention. Here we report that metformin significantly inhibited human epidermoid A431 tumor xenograf...

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Bibliographic Details
Main Authors: Chaudhary, Sandeep C., Kurundkar, Deepali, Elmets, Craig A., Kopelovich, Levy, Athar, Mohammad
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476735/
https://ncbi.nlm.nih.gov/pubmed/22540890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1751-1097.2012.01165.x
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