Serratia marcescens Induces Apoptotic Cell Death in Host Immune Cells via a Lipopolysaccharide- and Flagella-dependent Mechanism

Injection of Serratia marcescens into the blood (hemolymph) of the silkworm, Bombyx mori, induced the activation of c-Jun NH(2)-terminal kinase (JNK), followed by caspase activation and apoptosis of blood cells (hemocytes). This process impaired the innate immune response in which pathogen cell wall...

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Detalhes bibliográficos
Main Authors: Ishii, Kenichi, Adachi, Tatsuo, Imamura, Katsutoshi, Takano, Shinya, Usui, Kimihito, Suzuki, Kazushi, Hamamoto, Hiroshi, Watanabe, Takeshi, Sekimizu, Kazuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476324/
https://ncbi.nlm.nih.gov/pubmed/22859304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399667
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