Optimal Ratio of Transcription Factors for Somatic Cell Reprogramming

Somatic cell reprogramming is achieved by four reprogramming transcription factors (RTFs), Oct3/4, Sox2, Klf4, and c-Myc. However, in addition to the induction of pluripotent cells, these RTFs also generate pseudo-pluripotent cells, which do not show Nanog promoter activity. Therefore, it should be...

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Bibliographic Details
Main Authors: Nagamatsu, Go, Saito, Shigeru, Kosaka, Takeo, Takubo, Keiyo, Kinoshita, Taisuke, Oya, Mototsugu, Horimoto, Katsuhisa, Suda, Toshio
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476294/
https://ncbi.nlm.nih.gov/pubmed/22955270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380683
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