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Phosphatidylinositol-4-phosphate 5-Kinase Isoforms Exhibit Acyl Chain Selectivity for Both Substrate and Lipid Activator

Phosphatidylinositol 4,5-bisphosphate is mostly produced in the cell by phosphatidylinositol-4-phosphate 5-kinases (PIP5K) and has a crucial role in numerous signaling events. Here we demonstrate that in vitro all three isoforms of PIP5K, α, β, and γ, discriminate among substrates with different acy...

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Detalhes bibliográficos
Main Authors: Shulga, Yulia V., Anderson, Richard A., Topham, Matthew K., Epand, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476263/
https://ncbi.nlm.nih.gov/pubmed/22942276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.370155
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