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Evaluation of Riproximin Binding Properties Reveals a Novel Mechanism for Cellular Targeting
Riproximin is a cytotoxic type II ribosome-inactivating protein showing high selectivity for tumor cell lines. Its binding to cell surface glycans is crucial for subsequent internalization and cytotoxicity. In this paper, we describe a unique mechanism of interaction and discuss its implications for...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476256/ https://ncbi.nlm.nih.gov/pubmed/22872642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.368548 |
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