Evaluation of Riproximin Binding Properties Reveals a Novel Mechanism for Cellular Targeting

Riproximin is a cytotoxic type II ribosome-inactivating protein showing high selectivity for tumor cell lines. Its binding to cell surface glycans is crucial for subsequent internalization and cytotoxicity. In this paper, we describe a unique mechanism of interaction and discuss its implications for...

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Bibliographic Details
Main Authors: Bayer, Helene, Essig, Katharina, Stanzel, Sven, Frank, Martin, Gildersleeve, Jeffrey C., Berger, Martin R., Voss, Cristina
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476256/
https://ncbi.nlm.nih.gov/pubmed/22872642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.368548
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