Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome

The Staphylococcus aureus pore-forming toxin PVL is most likely causative for life-threatening necrotizing infections, which are characterized by massive tissue inflammation and necrosis. Whereas the cytotoxic action of PVL on human neutrophils is already well established, the PVL effects on other s...

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Hlavní autoři: Holzinger, Dirk, Gieldon, Laura, Mysore, Vijayashree, Nippe, Nadine, Taxman, Debra J., Duncan, Joseph A., Broglie, Peter M., Marketon, Kristina, Austermann, Judith, Vogl, Thomas, Foell, Dirk, Niemann, Silke, Peters, Georg, Roth, Johannes, Löffler, Bettina
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2012
Témata:
Inflammation, Extracellular Mediators, & Effector Molecules
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476237/
https://ncbi.nlm.nih.gov/pubmed/22892107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0112014
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