Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression

TGF-β plays a dual role in epithelial carcinogenesis with the potential to either suppress or promote tumor progression. We found that levels of Smad3 mRNA, a critical mediator of TGF-β signaling, are reduced by ~60% in human breast cancer. We therefore used conditionally immortalized mammary epithe...

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Autori principali: Kohn, Ethan A., Yang, Yu-an, Du, Zhijun, Nagano, Yoshiko, Van Schyndle, Catherine M.H., Herrmann, Michelle A., Heldman, Madeleine, Chen, Jin-Qiu, Stuelten, Christina H., Flanders, Kathleen C., Wakefield, Lalage M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475765/
https://ncbi.nlm.nih.gov/pubmed/22878587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0136-T
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