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Aging Mechanism of Soman Inhibited Acetylcholinesterase

Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nervous system that hydrolyses neurotransmitter acetylcholine (ACh) and terminates synaptic signals. The catalytic serine of AChE can be phosphonylated by soman, one of the most potent nerve agents, and subsequently undergo an aging...

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Detalhes bibliográficos
Main Authors: Sirin, Gulseher Sarah, Zhou, Yanzi, Lior-Hoffmann, Lee, Wang, Shenglong, Zhang, Yingkai
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475498/
https://ncbi.nlm.nih.gov/pubmed/22984913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp307790v
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