Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr(−/−) mice fed on a high-fat diet

The propensity of LDLs (low-density lipoproteins) for aggregation and/or oxidation has been linked to their sphingolipid content, specifically the levels of SM (sphingomyelin) and ceramide. To investigate this association in vivo, ldlr (LDL receptor)-null mice (ldlr(−/−)) were fed on a modified (ath...

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Main Authors: Deevska, Gergana M., Sunkara, Manjula, Morris, Andrew J., Nikolova-Karakashian, Mariana N.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2012
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475451/
https://ncbi.nlm.nih.gov/pubmed/22712892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120036
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