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Signal initiation by preTCR and TCRγδ in early thymocyte progenitors does not require extracellular domains previously implicated in receptor oligomerization
Whether thymocytes adopt an αβ or a γδ T cell fate in the thymus is determined at a checkpoint (β-selection) by the relatively weak or strong signals that are delivered by either the pre-T cell receptor (preTCR) or the γδ TCR, respectively. However, how these signals are initiated, and how different...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3475409/ https://ncbi.nlm.nih.gov/pubmed/21775286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001765 |
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