TPC Proteins Are Phosphoinositide-activated Sodium-selective Ion Channels in Endosomes and Lysosomes

Mammalian Two-Pore Channels (TPC1, 2; TPCN1, TPCN2) encode ion channels in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal calcium release triggered by the second messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). By directly recording TPCs in endolyso...

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Hauptverfasser: Wang, Xiang, Zhang, Xiaoli, Dong, Xian-ping, Samie, Mohammad, Li, Xinran, Cheng, Xiping, Goschka, Andrew, Shen, Dongbiao, Zhou, Yandong, Harlow, Janice, Zhu, Michael X., Clapham, David E., Ren, Dejian, Xu, Haoxing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475186/
https://ncbi.nlm.nih.gov/pubmed/23063126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.08.036
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