Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

A significant portion of the genome is transcribed as long non-coding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific...

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Autori principali: Morán, Ignasi, Akerman, İldem, van de Bunt, Martijn, Xie, Ruiyu, Benazra, Marion, Nammo, Takao, Arnes, Luis, Nakić, Nikolina, García-Hurtado, Javier, Rodríguez-Seguí, Santiago, Pasquali, Lorenzo, Sauty-Colace, Claire, Beucher, Anthony, Scharfmann, Raphael, van Arensbergen, Joris, Johnson, Paul R, Berry, Andrew, Lee, Clarence, Harkins, Timothy, Gmyr, Valery, Pattou, François, Kerr-Conte, Julie, Piemonti, Lorenzo, Berney, Thierry, Hanley, Neil A, Gloyn, Anna L, Sussel, Lori, Langman, Linda, Brayman, Kenneth L, Sander, Maike, McCarthy, Mark I., Ravassard, Philippe, Ferrer, Jorge
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475176/
https://ncbi.nlm.nih.gov/pubmed/23040067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.08.010
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