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Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119

Access to the ciliary membrane for trans-membrane or membrane-associated proteins is a regulated process. Previously, we have shown that the closely homologous small G proteins Arl2 and Arl3 allosterically regulate prenylated cargo release from PDEδ. UNC119/HRG4 is responsible for ciliary delivery o...

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Detalhes bibliográficos
Main Authors: Ismail, Shehab A, Chen, Yong-Xiang, Miertzschke, Mandy, Vetter, Ingrid R, Koerner, Carolin, Wittinghofer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474929/
https://ncbi.nlm.nih.gov/pubmed/22960633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.257
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