The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo

Human single-stranded DNA-binding protein 1 (hSSB1), encoded by OBFC2B, was recently characterized as an essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic stability. Here, we report that loss of Obfc2b in mice results in perinatal lethality characterized by...

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Detalhes bibliográficos
Main Authors: Feldhahn, Niklas, Ferretti, Elisabetta, Robbiani, Davide F, Callen, Elsa, Deroubaix, Stephanie, Selleri, Licia, Nussenzweig, Andre, Nussenzweig, Michel C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474923/
https://ncbi.nlm.nih.gov/pubmed/22940690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.247
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