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Structure and Dynamics of the Aβ(21–30) Peptide from the Interplay of NMR Experiments and Molecular Simulations

We combine molecular dynamics simulations and new high-field NMR experiments to describe the solution structure of the Aβ(21–30) peptide fragment that may be relevant for understanding structural mechanisms related to Alzheimer’s disease. By using two different empirical force-field combinations, we...

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Hlavní autoři: Fawzi, Nicolas L., Phillips, Aaron H., Ruscio, Jory Z., Doucleff, Michaeleen, Wemmer, David E., Head-Gordon, Teresa
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474854/
https://ncbi.nlm.nih.gov/pubmed/18412346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710366c
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