Involvement of CXCR4 Chemokine Receptor in Metastastic HER2-Positive Esophageal Cancer

A functional linkage of the structurally unrelated receptors HER2 and CXCR4 has been suggested for breast cancer but has not been evaluated for esophageal carcinoma. The inhibition of HER2 leads to a reduction of primary tumor growth and metastases in an orthotopic model of esophageal carcinoma. The...

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Main Authors: Gros, Stephanie J., Kurschat, Nina, Drenckhan, Astrid, Dohrmann, Thorsten, Forberich, Evelyn, Effenberger, Katharina, Reichelt, Uta, Hoffman, Robert M., Pantel, Klaus, Kaifi, Jussuf T., Izbicki, Jakob R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474831/
https://ncbi.nlm.nih.gov/pubmed/23082154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047287
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