Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials

Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites. Artemisinins are embryotoxic in animal models...

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Detalhes bibliográficos
Main Authors: Copple, Ian M, Mercer, Amy E, Firman, James, Donegan, Gail, Herpers, Bram, Wong, Michael HL, Chadwick, James, Bringela, Andreia D, Cristiano, Maria LS, van de Water, Bob, Ward, Stephen A, O’Neill, Paul M, Park, B Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474437/
https://ncbi.nlm.nih.gov/pubmed/22669474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00154
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