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Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer (ELP(BC)) self-assembles at 37°C into sphe...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3474318/ https://ncbi.nlm.nih.gov/pubmed/22417133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl300630c |
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