The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA

Genome-wide genotyping of a cohort using pools rather than individual samples has long been proposed as a cost-saving alternative for performing genome-wide association (GWA) studies. However, successful disease gene mapping using pooled genotyping has thus far been limited to detecting common varia...

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Autors principals: Chiang, Charleston W. K., Gajdos, Zofia K. Z., Korn, Joshua M., Butler, Johannah L., Hackett, Rachel, Guiducci, Candace, Nguyen, Thutrang T., Wilks, Rainford, Forrester, Terrence, Henderson, Katherine D., Le Marchand, Loic, Henderson, Brian E., Haiman, Christopher A., Cooper, Richard S., Lyon, Helen N., Zhu, Xiaofeng, McKenzie, Colin A., Palmer, Mark R., Hirschhorn, Joel N.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474315/
https://ncbi.nlm.nih.gov/pubmed/21424828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-011-0974-0
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