Sequential interaction of chloride and proton ions with the fast gate steer the voltage-dependent gating in ClC-2 chloride channels

The interaction of either H(+) or Cl(−) ions with the fast gate is the major source of voltage (V(m)) dependence in ClC Cl(−) channels. However, the mechanism by which these ions confer V(m) dependence to the ClC-2 Cl(−) channel remains unclear. By determining the V(m) dependence of normalized condu...

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Detalhes bibliográficos
Main Authors: Sánchez-Rodríguez, Jorge E, De Santiago-Castillo, José A, Contreras-Vite, Juan Antonio, Nieto-Delgado, Pablo G, Castro-Chong, Alejandra, Arreola, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Molecular and Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473282/
https://ncbi.nlm.nih.gov/pubmed/22753549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.232660
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