The Ionic and Hydrophobic Interactions Are Required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 are major hemoglobinases and potential antimalarial drug targets. Our previous studies demonstrated that these enzymes are equipped with specific domains for specific functions. Structural and functional analysis of falcipains...

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Main Authors: Sundararaj, Srinivasan, Singh, Deepak, Saxena, Ajay K., Vashisht, Kapil, Sijwali, Puran S., Dixit, Rajnikant, Pandey, Kailash C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473063/
https://ncbi.nlm.nih.gov/pubmed/23077573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047227
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