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A Combination of 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation Studies of Benzimidazole-Quinolinone Derivatives as iNOS Inhibitors

Inducible Nitric Oxide Synthase (iNOS) has been involved in a variety of diseases, and thus it is interesting to discover and optimize new iNOS inhibitors. In previous studies, a series of benzimidazole-quinolinone derivatives with high inhibitory activity against human iNOS were discovered. In this...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Hao, Zan, Jinhang, Yu, Guangyun, Jiang, Ming, Liu, Peixun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Molecular Diversity Preservation International (MDPI) 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472740/
https://ncbi.nlm.nih.gov/pubmed/23109848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms130911210
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