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Ubiquitin ligase RNF123 Mediates Degradation of Heterochromatin Protein 1α and β in Lamin A/C Knock-Down Cells
BACKGROUND: The nuclear lamina is a key determinant of nuclear architecture, integrity and functionality in metazoan nuclei. Mutations in the human lamin A gene lead to highly debilitating genetic diseases termed as laminopathies. Expression of lamin A mutations or reduction in levels of endogenous...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471868/ https://ncbi.nlm.nih.gov/pubmed/23077635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047558 |
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