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Lamin A Rod Domain Mutants Target Heterochromatin Protein 1α and β for Proteasomal Degradation by Activation of F-Box Protein, FBXW10
BACKGROUND: Lamins are major structural proteins of the nucleus and contribute to the organization of various nuclear functions. Mutations in the human lamin A gene cause a number of highly degenerative diseases, collectively termed as laminopathies. Cells expressing lamin mutations exhibit abnormal...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2869352/ https://ncbi.nlm.nih.gov/pubmed/20498703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010620 |
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