Inhibition of BDNF in Multiple Myeloma Blocks Osteoclastogenesis via Down-Regulated Stroma-Derived RANKL Expression Both In Vitro and In Vivo

Brain-derived neurotrophic factor (BDNF) was recently identified as a factor produced by multiple myeloma (MM) cells, which may contribute to bone resorption and disease progression in MM, though the molecular mechanism of this process is not well understood. The purpose of this study was to test th...

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Detalhes bibliográficos
Main Authors: Ai, Li-Sha, Sun, Chun-Yan, Zhang, Lu, Zhou, Shun-Chang, Chu, Zhang-Bo, Qin, You, Wang, Ya-Dan, Zeng, Wei, Yan, Han, Guo, Tao, Chen, Lei, Yang, Di, Hu, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471864/
https://ncbi.nlm.nih.gov/pubmed/23077504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046287
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