Inhibition of BDNF in Multiple Myeloma Blocks Osteoclastogenesis via Down-Regulated Stroma-Derived RANKL Expression Both In Vitro and In Vivo

Brain-derived neurotrophic factor (BDNF) was recently identified as a factor produced by multiple myeloma (MM) cells, which may contribute to bone resorption and disease progression in MM, though the molecular mechanism of this process is not well understood. The purpose of this study was to test th...

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Main Authors: Ai, Li-Sha, Sun, Chun-Yan, Zhang, Lu, Zhou, Shun-Chang, Chu, Zhang-Bo, Qin, You, Wang, Ya-Dan, Zeng, Wei, Yan, Han, Guo, Tao, Chen, Lei, Yang, Di, Hu, Yu
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471864/
https://ncbi.nlm.nih.gov/pubmed/23077504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046287
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