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A Screen for Selective Killing of Cells with Chromosomal Instability Induced by a Spindle Checkpoint Defect
BACKGROUND: The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with poor clinical outcomes such as drug resistance and metastasis. As CIN is not fo...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471812/ https://ncbi.nlm.nih.gov/pubmed/23077619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047447 |
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