The First Structure of a Lantibiotic Immunity Protein, SpaI from Bacillus subtilis, Reveals a Novel Fold

Lantibiotics are peptide-derived antibiotics that inhibit the growth of Gram-positive bacteria via interactions with lipid II and lipid II-dependent pore formation in the bacterial membrane. Due to their general mode of action the Gram-positive producer strains need to express immunity proteins (Lan...

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Main Authors: Christ, Nina A., Bochmann, Sophie, Gottstein, Daniel, Duchardt-Ferner, Elke, Hellmich, Ute A., Düsterhus, Stefanie, Kötter, Peter, Güntert, Peter, Entian, Karl-Dieter, Wöhnert, Jens
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471728/
https://ncbi.nlm.nih.gov/pubmed/22904324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401620
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